Ranked by engagement

Top topics — all time page 32

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 32 of 40

Topic	Participants	Replies	Views	Activity
Review cadence: how often is a page actually re-checked? Documentation › Doc review maintainership review date promoted to docs Solved Asking directly, because I could not find a straight answer: Review cadence: how often is a page actually re-checked? Nominating something for promotion into the documentation commons. The topic in question…	+20	24	20k	15mo
SURMOUNT-4 and what withdrawal data does and does not tell an individual Compounds › Tirzepatide SURPASS programme randomised trial effect size SURMOUNT programme Solved SURMOUNT-4 and what withdrawal data does and does not tell an individual — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 8 ( JAMA , 2022)…		4	42k	11mo
Coming back to: Swirling versus inverting versus leaving it alone Practice › Reconstitution reconstitution concentration maths syringe units Solved Swirling versus inverting versus leaving it alone Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how quickly…	+20	24	16k	26d
Why most self-reports here are not experiments, and that is fine Research Methods › N-of-1 designs confounding worked example data table effect size Closed Why most self-reports here are not experiments, and that is fine — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in…		2	46k	11mo
Training through a dose escalation week Nutrition & Training › Resistance training lean mass loss DXA fatigue Training through a dose escalation week — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes about. I have…		4	42k	20mo
Follow-up: The retatrutide phase 2 obesity paper, read closely Compounds › Retatrutide retatrutide randomised trial preprint effect size The retatrutide phase 2 obesity paper, read closely — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not think it…	+19	23	16k	2d
Getting a referral rather than a refusal Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes Getting a referral rather than a refusal — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the difference and I would…	+8	12	32k	2mo
Tirzepatide storage and stability: what is published versus what is assumed Compounds › Tirzepatide SURPASS programme randomised trial SURMOUNT programme effect size On the subject in the title: Tirzepatide storage and stability: what is published versus what is assumed Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read…	+17	21	17k	12d
Request: a diff view for wiki revisions Meta › Feature requests site feedback wiki post translation Request: a diff view for wiki revisions — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps…	+26	30	3.1k	19mo
Whether an aggregate is worth publishing at all: a disputed topic Data & Tools › Datasets confounding site feedback observational data On the subject in the title: Whether an aggregate is worth publishing at all: a disputed topic Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+20	24	18k	13mo
Conditions that change the calculus rather than forbidding it Safety › Contraindications disordered eating pregnancy & planning pancreatitis delayed gastric emptying Conditions that change the calculus rather than forbidding it Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+28	32	6.1k	1d
Follow-up: Reconciling a label claim with a content assay Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Reconciling a label claim with a content assay Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it anywhere.…	+26	30	6.5k	14d
Second pass at: Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues amylin analogues effect size cagrilintide cagrisema Closed Second pass at: Historical amylin analogues and what happened to them — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim…	+15	19	22k	18mo
Composite endpoints and the component doing the work Evidence › Trials randomised trial surrogate endpoints open label discontinuation & dropout Solved Under review Composite endpoints and the component doing the work Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I do…	+3	7	33k	13h
Retatrutide's phase 2 heart-rate signal and how to think about it Compounds › Retatrutide randomised trial preprint TRIUMPH programme retatrutide On the subject in the title: Retatrutide's phase 2 heart-rate signal and how to think about it Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019) cited in support of a claim…	+19	23	20k	7mo
A calculator that gives a right answer to the wrong question Data & Tools › Calculators concentration maths worked example site feedback syringe units Posting this under the heading it deserves: A calculator that gives a right answer to the wrong question Everything below is what sits behind that. I would like to understand what this number means before I…	+32	36	1.9k	17h
Coming back to: Lurking for two months before posting: was that the right call? Start Here › Welcome beginner friendly trust levels onboarding Solved The question in the title: Lurking for two months before posting: was that the right call? I will give what I have already checked below so nobody repeats it. I want to check my reasoning rather than get a…	+28	32	3.3k	11mo
Second pass at: Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics missed dose worked example semaglutide Posting this under the heading it deserves: Second pass at: Albumin binding and how it produces a long half-life Everything below is what sits behind that. I would like to understand what this number means…	+7	11	31k	17mo
Non-inferiority margins: how they are chosen and how they are abused — a second dataset Evidence › Trials randomised trial discontinuation & dropout intention to treat estimand Non-inferiority margins: how they are chosen and how they are abused — a second dataset — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with…	+32	37	574	5mo
Hello from a laboratory that does not do peptides — does this still hold? Lounge › Introductions beginner friendly onboarding Asking directly, because I could not find a straight answer: Hello from a laboratory that does not do peptides — does this still hold? Lower-stakes topic, but the sourcing rule still applies if anyone makes a…	+1	5	35k	19mo
Pages past their review date, listed Meta › Wiki maintenance wiki post maintainership review date moderation Pages past their review date, listed Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation commons. The topic in question…	+26	30	6.4k	10mo
Follow-up: I have no scientific background — can I still follow the analytics categories? Start Here › Welcome guidelines beginner friendly trust levels onboarding Solved Asking directly, because I could not find a straight answer: I have no scientific background — can I still follow the analytics categories? Question in the title. Context below, and I have tried to include…	+15	19	15k	1mo
Currency conversion and the cost you did not see Sourcing › Payments payments research use only documentation quality Currency conversion and the cost you did not see — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the maintainers asked for.…		2	44k	2mo
About the Resistance training category Nutrition & Training › Resistance training lean mass loss fatigue DXA Pinned Wiki Programming while losing weight quickly, realistic expectations, and recovery. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…		4	40k	17d
What steady state means for the decision to escalate Practice › Dosing & titration semaglutide titration tirzepatide missed dose Solved What steady state means for the decision to escalate — that is the question, and I have not found it answered plainly anywhere I have looked. Reporting something rather than asking about it, in case the…	+31	35	2k	1d
Follow-up: Is "synergy" the right word for the combination data? Compounds › Cagrilintide & amylin analogues cagrilintide cagrisema amylin analogues effect size Solved Under review Is "synergy" the right word for the combination data? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…		2	41k	14mo
Follow-up: Why "dose equivalence" between different incretin analogues is a weak concept Practice › Dosing & titration dose reduction worked example tirzepatide missed dose Solved Asking directly, because I could not find a straight answer: Why "dose equivalence" between different incretin analogues is a weak concept Reporting something rather than asking about it, in case the pattern…	+7	11	26k	9mo
Revisiting: Body image changing more slowly than the body Wellbeing › Mental health disordered eating mood beginner friendly Solved Posting this under the heading it deserves: Revisiting: Body image changing more slowly than the body Everything below is what sits behind that. General question, not a request for advice about my own care —…	+5	9	28k	8h
An orphaned page with no inbound links — the long version Meta › Wiki maintenance review date wiki post citation check Posting this under the heading it deserves: An orphaned page with no inbound links — the long version Everything below is what sits behind that. Process question about how this site works. I have read the…	+14	18	21k	10mo
Revisiting: A field-by-field walk through a certificate of analysis Analytics › COA interpretation certificate of analysis documentation quality reference standards amino acid analysis Revisiting: A field-by-field walk through a certificate of analysis Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I…	+37	41	656	3mo