Ranked by engagement

Top topics — this year page 3

Ranked by replies, likes and views over this year, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,076 topics · page 3 of 14

Topic	Participants	Replies	Views	Activity
Journal club: orforglipron phase 2 and the non-peptide question Evidence › Journal club journal club estimand randomised trial Journal club: orforglipron phase 2 and the non-peptide question Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support…	+120	132	13k	1d
Reading a home test result without over-claiming Analytics › Home & field testing ELISA documentation quality LOD & LOQ third-party testing Reading a home test result without over-claiming — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked. retatrutide has a…	+124	137	19k	7h
Coming back to: Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics missed dose semaglutide worked example Closed Posting this under the heading it deserves: Washout: how long is long enough, and for what purpose Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+128	139	3k	3mo
Follow-up: Search filters: what is missing Meta › Site feedback guidelines site feedback moderation On the subject in the title: Search filters: what is missing Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic in question keeps being…	+126	141	1.6k	29d
Which panel is worth repeating and which is worth ignoring Clinical › Bloodwork eGFR & renal function liver enzymes HbA1c Solved The question in the title: Which panel is worth repeating and which is worth ignoring I will give what I have already checked below so nobody repeats it. General question, not a request for advice about my…	+125	133	17k	10mo
Reading an interaction checker output critically Practice › Interactions metformin delayed gastric emptying needs a source On the subject in the title: Reading an interaction checker output critically Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking rather than…	+144	152	3k	4mo
Counter-ion content and its effect on measured mass Analytics › Mass spectrometry high-resolution MS charge states MALDI-TOF LC-MS Solved On the subject in the title: Counter-ion content and its effect on measured mass Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. retatrutide has a…	+100	108	45k	12mo
What a certificate commits its issuer to Analytics › COA interpretation reference standards batch & lot numbers amino acid analysis The question in the title: What a certificate commits its issuer to I will give what I have already checked below so nobody repeats it. A documentation question rather than an analytical one. I have a…	+101	116	26k	19h
Carryover and the ghost peak from last week's standard — what changed since Analytics › HPLC & UHPLC gradient method data table HPLC UV & DAD detection Solved Carryover and the ghost peak from last week's standard — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the…	+98	114	37k	22d
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Compounds › Oral incretins oral semaglutide randomised trial PIONEER programme SOUL trial Solved Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SURPASS-4 ( Lancet , 2021)…	+130	135	11k	7mo
Semaglutide half-life: where the 165 to 184 hour figure comes from Compounds › Semaglutide semaglutide effect size randomised trial type 2 diabetes Wiki Semaglutide half-life: where the 165 to 184 hour figure comes from — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with STEP 4 ( JAMA , 2021) and…	+128	145	3k	4mo
[2026 update] A vial that will not fully dissolve: what to check and in what order Practice › Reconstitution concentration maths dead volume bacteriostatic water syringe units Solved Posting this under the heading it deserves: A vial that will not fully dissolve: what to check and in what order Everything below is what sits behind that. Practical question with the units stated, because I…	+114	128	20k	1mo
Journal club: SUSTAIN 6 and its retinopathy signal Evidence › Journal club estimand effect size risk of bias journal club Under review On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I do not think it…	+110	122	46k	1d
Why we ask for units every single time, with three examples of what goes wrong Start Here › How to Ask worked example onboarding beginner friendly guidelines Why we ask for units every single time, with three examples of what goes wrong — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below,…	+118	135	2.2k	11d
Journal club: what we got wrong in an earlier session Evidence › Journal club number needed to treat effect size randomised trial journal club On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before posting; the…	+114	125	2.5k	23h
Run-in periods and the population they select Evidence › Trials surrogate endpoints discontinuation & dropout estimand randomised trial On the subject in the title: Run-in periods and the population they select Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+130	142	7.3k	1mo
Coming back to: Why a preprint's supplementary material is often the best part Evidence › Preprints risk of bias effect size preprint Under review Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021) with STEP 4 (…	+109	116	36k	2d
Coming back to: Why quantitation is the hard part, not detection Analytics › Home & field testing third-party testing documentation quality ELISA LOD & LOQ Why quantitation is the hard part, not detection — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first, because I know what the first three replies…	+86	92	54k	8mo
Revisiting: The best-written scientific paper you have read Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: Revisiting: The best-written scientific paper you have read Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule still applies if…	+102	121	21k	1h
Revisiting: Reading a denial letter as a specification for your appeal Access › Insurance & coverage prior authorisation insurance formulary appeals Posting this under the heading it deserves: Revisiting: Reading a denial letter as a specification for your appeal Everything below is what sits behind that. A coverage question with the paperwork detail…	+125	138	9.4k	10mo
Follow-up: Why appetite effects are mostly central Pharmacology › Receptor biology tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A documentation question rather than an analytical one. I have a certificate in front of me that reports a…	+86	90	61k	9mo
Reading a supplier's product description as a marketing document Compounds › Other compounds custom synthesis needs a source mislabelling On the subject in the title: Reading a supplier's product description as a marketing document Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019) cited in support of a claim I…	+86	97	62k	8mo
Which panel is worth repeating and which is worth ignoring — a second dataset Clinical › Bloodwork lipid panel liver enzymes eGFR & renal function lipase & amylase Asking directly, because I could not find a straight answer: Which panel is worth repeating and which is worth ignoring — a second dataset General question, not a request for advice about my own care — I know…	+108	117	46k	4mo
Request: a per-category review queue Meta › Feature requests site feedback translation wiki post Request: a per-category review queue Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation commons. The topic in question…	+125	136	13k	2h
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Evidence › Journal club number needed to treat risk of bias journal club effect size Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+81	90	54k	9mo
[2026 update] Journal club: is percentage weight change the right endpoint? Evidence › Journal club effect size risk of bias randomised trial Journal club: is percentage weight change the right endpoint? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021) with…	+105	118	18k	11mo
TB-500 and thymosin beta-4: the fragment versus the protein Compounds › Repair & healing peptides observational data TB-500 BPC-157 preprint TB-500 and thymosin beta-4: the fragment versus the protein Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…	+107	118	22k	11mo
Where to report an adverse event officially, by region — a second dataset Safety › Adverse events gallbladder delayed gastric emptying vomiting hypoglycaemia On the subject in the title: Where to report an adverse event officially, by region — a second dataset Working notes rather than a conclusion. Asking about a population rather than about a person. The…	+108	123	26k	8mo
Citing a preprint in a maintained document: our rule and its reasoning — does this still hold? Evidence › Preprints preprint needs a source effect size Solved Under review The question in the title: Citing a preprint in a maintained document: our rule and its reasoning — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER…	+103	115	24k	10mo
Converting between mg/mL and units per dose, both directions — the long version Practice › Reconstitution reconstitution worked example syringe units dead volume Converting between mg/mL and units per dose, both directions — the long version Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated,…	+110	132	1.7k	3mo