n.hartmann

TL2 Moderator · Palermo

Contributes reviews on supplier material. Based in Palermo.

Joined 17 November 2024 · last posted 1d

96 posts, newest first. Showing up to 150.

Packaging that arrived damaged: documenting it properly Replied, post #50 · Sourcing › Logistics · 27 Jul 2026 · 31 likes Picking up post #47: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
The five documentation pages worth reading before you post anything — a second dataset Replied, post #3 · marked as the solution · Start Here › Welcome · 27 Jul 2026 · 26 likes Marked solutions are the site's way of saying that someone asked a good question and someone else gave an answer that actually worked. It is not a competition and it…
Why the absence of controlled human data on BPC-157 matters more than people admit Replied, post #66 · Compounds › Repair & healing peptides · 25 Jul 2026 · 2 likes Why plausible mechanism is not evidence of effect: a mechanism that is chemically or biologically plausible can fail in practice for dozens of reasons —…
Follow-up: The most useful thing you learned here that was not the answer you came for Replied, post #31 · Lounge › Off topic · 22 Jul 2026 · 1 like I read post #29 twice before replying, because I had assumed the opposite. Humour: light, relevant humour is welcome. Cruel humour targeting individuals or groups is not.
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #38 · Compounds › Retatrutide · 18 Jul 2026 · 1 like TRIUMPH is phase 3 and it is ongoing. No phase 3 results exist. Nothing should be attributed to TRIUMPH because the trial has not finished. When it does, this page will…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #110 · Evidence › Journal club · 16 Jul 2026 · 0 likes Coming back to post #108, because the follow-up matters more than the original answer. PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide,…
How shortages have affected compounding permissions Replied, post #38 · Access › Shortages · 14 Jul 2026 · 4 likes Communication from suppliers: a supplier having supply problems usually communicates them. If a supplier goes silent, that is itself information.
Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #51 · Clinical › Comorbidities · 13 Jul 2026 · 9 likes Bariatric surgery history: altered anatomy after surgery affects absorption. That matters for oral medications and for reconstituted solutions. Discussing specific…
Follow-up: Reading an interaction checker output critically Replied, post #43 · Practice › Interactions · 12 Jul 2026 · 0 likes Food interactions: most interactions are absorption interactions. Some medications absorb better with food, others better on an empty stomach. With an incretin agonist…
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #57 · Analytics › HPLC & UHPLC · 9 Jul 2026 · 1 like post #56 answers the question as asked. The question underneath it is different. Gradient slope is the single biggest driver of apparent purity differences. A shallower…
Reading a rodent study on a secretagogue without over-extrapolating — the long version Replied, post #29 · Compounds › Secretagogues & GH axis · 8 Jul 2026 · 0 likes I read post #27 twice before replying, because I had assumed the opposite. Tesamorelin has an approved indication in HIV-associated lipodystrophy. That is the only…
[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #60 · Access › International · 6 Jul 2026 · 4 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Reflectance and photometric devices: precision in practice — a second dataset Replied, post #65 · Analytics › Home & field testing · 5 Jul 2026 · 0 likes What physical quantity does the device measure? A colorimetric or lateral-flow method typically responds to a class of chemistry rather than to a specific molecule. It…
I joined for one answer and stayed for a year — what changed my mind Replied, post #34 · Start Here › Welcome · 21 Jun 2026 · 0 likes Marked solutions are the site's way of saying that someone asked a good question and someone else gave an answer that actually worked. It is not a competition and it…
Second pass at: Which categories are strict and which are relaxed, honestly Replied, post #75 · Start Here › Welcome · 15 Jun 2026 · 8 likes I read post #73 twice before replying, because I had assumed the opposite. The moderation log is public. Every staff action is logged with the rule cited and the…
Tracking intake honestly when appetite is absent Replied, post #56 · Nutrition & Training › Protein & intake · 11 Jun 2026 · 0 likes Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as solid food. Using both together can help.
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #15 · Sourcing › Red flags · 3 Jun 2026 · 0 likes Anonymity: a supplier that will not disclose legal name, address, or responsible person is not operating in a way that allows accountability.
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #68 · Practice › Reconstitution · 2 Jun 2026 · 18 likes Swirling versus inverting versus leaving it alone: the vial can be gently warmed (hands around it) and swirled with a rolling motion. Vigorous shaking introduces air…
What I would want from a home test that does not exist yet Replied, post #2 · Analytics › Home & field testing · 1 Jun 2026 · 0 likes Picking up the opening post: that is the part I would want checked first. Enzyme assays: if you have an enzyme that reacts specifically with your compound, an…
Shoulders, tangent skims, and defensible integration Replied, post #5 · Analytics › HPLC & UHPLC · 31 May 2026 · 0 likes post #4 is right about the mechanism and I think understates the practical bit. Method validation is the demonstration that a method can separate the compound from its…
Research-use-only status: what it means legally and practically Replied, post #49 · Compounds › Other compounds · 28 May 2026 · 2 likes Why catalogue breadth is not evidence of anything: a supplier listing 500 compounds does not make the 450 untested ones likely to work. It makes them untested compounds…
Secretagogues and glucose tolerance: the mechanistic concern Replied, post #13 · Compounds › Secretagogues & GH axis · 26 May 2026 · 17 likes Evidence quality in the secretagogue literature is honestly weaker than in the incretin literature. Large randomised controlled trials are rare. Most evidence is…
Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #10 · Pharmacology › Pharmacokinetics · 24 May 2026 · 7 likes post #9 answers the question as asked. The question underneath it is different. Individual variation: people vary in how quickly they absorb, distribute, metabolise,…
Molecular mass of semaglutide and why the figure differs between sources Replied, post #59 · Compounds › Semaglutide · 19 May 2026 · 0 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Follow-up: Search filters: what is missing Replied, post #98 · Meta › Site feedback · 10 May 2026 · 0 likes Community norms: if you think a norm has drifted or is not being followed consistently, raising it here can prompt discussion and realignment.
Why this subcategory is stricter about sourcing than most Replied, post #26 · Compounds › Secretagogues & GH axis · 5 May 2026 · 6 likes GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like CJC-1295) cause the pituitary to release growth…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #55 · Sourcing › Logistics · 29 Apr 2026 · 8 likes post #54 is right about the mechanism and I think understates the practical bit. At what point is a parcel genuinely a problem: if it was despatched weeks ago and there…
Converting between mg/mL and units per dose, both directions — the long version Replied, post #123 · Practice › Reconstitution · 25 Apr 2026 · 18 likes post #122 answers the question as asked. The question underneath it is different. Choosing a concentration on purpose rather than by accident: starting with "I want to…
Foaming during reconstitution and whether it matters — the long version Replied, post #109 · Practice › Reconstitution · 23 Apr 2026 · 10 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #153 · Access › Pricing · 20 Apr 2026 · 6 likes Discount programmes and coupons: manufacturers often offer coupons that reduce out-of-pocket costs if insurance is not covering or is covering at a high copay. These…
Converting between mg/mL and units per dose, both directions — the long version Replied, post #29 · Practice › Reconstitution · 19 Apr 2026 · 11 likes A 10 mg vial reconstituted three different ways: 1 mL diluent gives 10 mg/mL, 2 mL gives 5 mg/mL, 4 mL gives roughly 2.5 mg/mL. The arithmetic is the same; the…
Grapefruit: why this class is not the class that cares Replied, post #79 · Practice › Interactions · 25 Mar 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Replied, post #56 · Data & Tools › Calculators · 24 Feb 2026 · 22 likes Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies.…
Stepping down deliberately, and how to do it without losing progress Replied, post #63 · Practice › Dosing & titration · 23 Feb 2026 · 1 like The arithmetic of an intermediate dose: if the label says 1.0 mg and 2.0 mg, a dose strictly between them is off-label by definition. Some people compute it anyway. The…
Mass error in ppm: the arithmetic and the caveat Replied, post #15 · Analytics › Mass spectrometry · 12 Feb 2026 · 0 likes post #14 is right about the mechanism and I think understates the practical bit. Charge states observed: for semaglutide (4113.6 Da) the doubly charged ion appears at…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #43 · Research Methods › N-of-1 designs · 6 Feb 2026 · 11 likes I read post #41 twice before replying, because I had assumed the opposite. When to run an n-of-1: this design works when you want to know whether a treatment works for…
What "marked as solution" means and who gets to mark it — does this still hold? Replied, post #38 · Start Here › Welcome · 3 Feb 2026 · 7 likes Trust levels accumulate over time and they give you access to small things like the ability to edit your own posts without a timestamp. They are not a status symbol and…
Is there a ceiling dose beyond which semaglutide stops adding benefit? Started this topic · Compounds › Semaglutide · 28 Jan 2026 · 43 likes Is there a ceiling dose beyond which semaglutide stops adding benefit? I have a specific reason for asking rather than idle curiosity, and the context is below. I have…
A partial dose because the pen emptied mid-injection Replied, post #31 · Practice › Administration · 8 Jan 2026 · 23 likes Angle of injection: 90 degrees into pinched tissue ensures subcutaneous placement. It is not always necessary and shallower angles can work, but 90 degrees into a small…
When to stop reading forums, including this one Replied, post #72 · Wellbeing › Mental health · 6 Jan 2026 · 14 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Replied, post #8 · Practice › Storage & stability · 28 Dec 2025 · 2 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Moderation log format change Replied, post #15 · Meta › Announcements · 18 Dec 2025 · 0 likes Coming back to post #13, because the follow-up matters more than the original answer. Staff announcements, policy changes, and scheduled maintenance. Read-only except…
Revisiting: Review: an evidence digest and the citation check that delayed it Replied, post #37 · Documentation › Doc review · 7 Dec 2025 · 20 likes Review of promoted topics: when a topic is nominated for promotion to a maintained documentation page, the draft is posted here. Community review happens before…
Persistent vomiting and the threshold for seeking help Replied, post #74 · Safety › Adverse events · 22 Nov 2025 · 1 like Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a…
Why "add 2 mL" is not an instruction Replied, post #8 · Practice › Reconstitution · 15 Nov 2025 · 2 likes Swirling versus inverting versus leaving it alone: the vial can be gently warmed (hands around it) and swirled with a rolling motion. Vigorous shaking introduces air…
Why oral semaglutide needs an absorption enhancer at all Replied, post #49 · Compounds › Oral incretins · 12 Nov 2025 · 29 likes I read post #47 twice before replying, because I had assumed the opposite. PIONEER programme is phase 3 for oral semaglutide. The trials cover multiple indications and…
[2026 update] A single out-of-range value on an otherwise normal panel Replied, post #19 · Clinical › Bloodwork · 1 Nov 2025 · 11 likes Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening. Comparing results from different times of day is…
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #24 · Compounds › Tirzepatide · 19 Oct 2025 · 25 likes Storage and stability: published data on licensed tirzepatide formulations exists and is worth reading directly rather than through summarised claims. Reconstituted…
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Replied, post #37 · Clinical › Special populations · 18 Oct 2025 · 1 like Adolescents: a distinct evidence base exists. The compounds are not approved for routine adolescent obesity but are being studied. Adolescent physiology and psychology…
Second pass at: Robustness: the parameters worth deliberately varying Replied, post #17 · Analytics › Method validation · 5 Oct 2025 · 8 likes Specificity: the method can distinguish the intended compound from related impurities and degradation products. Tested by comparing results on pure compounds, mixtures…
What this community means by "a source", in practical terms Replied, post #107 · Start Here › Welcome · 10 Sep 2025 · 22 likes Worth separating two things that post #103 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
Are there stupid questions here? A staff answer, at length Replied, post #126 · Start Here › Welcome · 29 Aug 2025 · 9 likes Welcome. The orientation materials are pinned at the top of this category and they take about an hour. They answer most of the questions a new member has and they save…
Follow-up: The decimal-point error, and the habit that catches it Replied, post #46 · Practice › Reconstitution · 22 Aug 2025 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Coming back to: Why quantitation is the hard part, not detection Replied, post #54 · Analytics › Home & field testing · 21 Aug 2025 · 0 likes post #53 is right about the mechanism and I think understates the practical bit. What physical quantity does the device measure? A colorimetric or lateral-flow method…
Second pass at: LOD and LOQ: definitions people get wrong Replied, post #7 · Analytics › Method validation · 20 Aug 2025 · 21 likes System suitability: injections run at the start of a batch to establish that the instrument and column are performing. Acceptance criteria typically include replicate…
Coming back to: Cross-border purchase rules within the EU Replied, post #17 · Regional › European Union · 19 Aug 2025 · 0 likes This follows post #14 rather than contradicting it. France: ANSM implements EU framework. Reimbursement has been narrower for weight management. Prescribing…
Immortal time bias in a claims-database study Replied, post #22 · Evidence › Study critique · 16 Aug 2025 · 21 likes Building consensus on which criticisms matter: if everyone agrees that the sample size is small but only you think that affects the conclusion, maybe your criticism is…
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #31 · Analytics › HPLC & UHPLC · 11 Aug 2025 · 0 likes Method validation is the demonstration that a method can separate the compound from its degradation products and impurities reliably. A method that cannot resolve an…
Follow-up: Why we hide unevidenced fraud accusations and log the hiding Replied, post #11 · Sourcing › Red flags · 27 Jul 2025 · 27 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #51 · Compounds › Oral incretins · 21 Jun 2025 · 27 likes On post #47 — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and…
Airline travel with a temperature-sensitive injectable — what changed since Replied, post #41 · Devices › Cold chain · 21 Jun 2025 · 2 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Half-life, steady state, and accumulation worked through Replied, post #94 · Pharmacology › Pharmacokinetics · 10 Jun 2025 · 0 likes Coming back to post #92, because the follow-up matters more than the original answer. Renal clearance: these compounds are cleared partly via the kidney. In severe…
Journal club: SURMOUNT-1, read without the press release Replied, post #134 · Evidence › Journal club · 10 Jun 2025 · 7 likes Session format: read the paper before posting. The discussion is much better when everyone has. Start with the estimand and population, then methods, then results, then…
A claim built entirely on a subgroup analysis Replied, post #80 · Evidence › Study critique · 6 Jun 2025 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Half-life, steady state, and accumulation worked through Replied, post #75 · Pharmacology › Pharmacokinetics · 6 Jun 2025 · 2 likes Individual variation: people vary in how quickly they absorb, distribute, metabolise, and excrete these compounds. That variation is partly genetic and partly due to…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #125 · Practice › Reconstitution · 4 Jun 2025 · 26 likes The decimal-point error: computing 5 mg / 2 mL as 0.25 mg/mL instead of 2.5 mg/mL is the most common arithmetic error in this subcategory. The habit that catches it:…
Triple agonism: additive, synergistic, or neither? Replied, post #51 · Compounds › Retatrutide · 29 May 2025 · 4 likes Picking up post #48: that is the part I would want checked first. Hepatic effects: glucagon receptor agonism promotes hepatic fat oxidation, which is mechanistically…
Antibiotics and a course of something with delayed emptying Replied, post #52 · Practice › Interactions · 29 May 2025 · 26 likes I read post #50 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
Pregnancy as an absolute contraindication Replied, post #107 · Safety › Contraindications · 21 May 2025 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Requesting a translation of an existing page Replied, post #16 · Documentation › Wiki requests · 10 May 2025 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #50 · Sourcing › Independent verification · 5 May 2025 · 4 likes Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and…
Transit times by route, from a logged dataset — the long version Replied, post #87 · Sourcing › Logistics · 28 Apr 2025 · 28 likes This follows post #84 rather than contradicting it. Documentation after arrival: photograph the parcel and its contents on arrival. If something later turns out wrong…
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #22 · Clinical › Comorbidities · 23 Apr 2025 · 14 likes Interactions between comorbidities: diabetes and kidney disease together change the risk calculation for hypoglycemia and for medication clearance. They are not…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #49 · Evidence › Journal club · 19 Apr 2025 · 0 likes SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective physiological endpoint. Notable because soft endpoints are avoided. Two…
BPC-157: what the rodent literature actually shows, and what it does not — a second… Replied, post #33 · Compounds › Repair & healing peptides · 11 Apr 2025 · 0 likes Worth separating two things that post #29 runs together. What would change the position on repair peptides: adequately powered, published, peer-reviewed randomised…
Consistent declarations and why they matter more than clever ones Replied, post #155 · Sourcing › Logistics · 9 Mar 2025 · 3 likes Documentation after arrival: photograph the parcel and its contents on arrival. If something later turns out wrong (damage, loss, wrong item) you have evidence of the…
About the Secretagogues & GH axis category Replied, post #3 · Compounds › Secretagogues & GH axis · 6 Mar 2025 · 0 likes As a member rather than staff: the most useful thing I did when I started reading this category was to work through the tag pages rather than the topic list. The topic…
Counter-ion form: the field almost nobody reports — one year on Replied, post #53 · Analytics › COA interpretation · 6 Mar 2025 · 9 likes I read post #51 twice before replying, because I had assumed the opposite. When a document puts the specification in the result column, it has told you the release…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #152 · Sourcing › Regulatory · 6 Mar 2025 · 2 likes Compounding and pharmacy rules: some jurisdictions allow a pharmacy to compound a drug that is not on the market under specific conditions. The conditions are strict…
Coming back to: Recording a dissent on a document rather than suppressing it Replied, post #43 · Documentation › Doc review · 4 Mar 2025 · 13 likes Multilingual versions: if a maintained page should exist in another language, suggesting it here with your willingness to help translate can make it happen.
Revisiting: Bug report: the reconstitution calculator and a rounding edge case Replied, post #87 · Data & Tools › Calculators · 12 Feb 2025 · 18 likes Offline use: all calculators are written in JavaScript and can be downloaded and run offline if desired. They do not require internet connectivity to function.
Canadian access and provincial variation Replied, post #75 · Regional › North America · 10 Feb 2025 · 0 likes Canada: Health Canada licenses compounds. Prescribing is provincial. Compounds are prescription-only. Coverage varies between public and private insurance.
Preservatives: function, testing, and limits Replied, post #4 · Pharmacology › Formulation chemistry · 22 Jan 2025 · 27 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Research-use-only status: what it means legally and practically — a second dataset Replied, post #64 · Compounds › Other compounds · 15 Jan 2025 · 11 likes Research-use-only status is a legal classification, not a safety classification. It means the compound is sold for laboratory use and not for human consumption or…
Why mass spectrometry cannot tell you about an epimer Replied, post #18 · Analytics › Mass spectrometry · 3 Jan 2025 · 10 likes I read post #16 twice before replying, because I had assumed the opposite. Resolution: "high resolution" commonly means
Feature request: should a dose-equivalence tool exist at all? Replied, post #4 · Data & Tools › Calculators · 25 Dec 2024 · 10 likes Mass error checking: enter your observed mass and theoretical mass and check whether the difference in ppm is within reasonable bounds for your instrument. Useful…
Retatrutide's phase 2 heart-rate signal and how to think about it — the long version Started this topic · Compounds › Retatrutide · 18 Dec 2024 · 11 likes Retatrutide's phase 2 heart-rate signal and how to think about it — the long version Writing it up because I had to work it out twice and would rather nobody else did.…
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #140 · Analytics › COA interpretation · 4 Dec 2024 · 29 likes post #139 is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct answer, and…
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #73 · Analytics › Method validation · 15 Nov 2024 · 23 likes post #72 answers the question as asked. The question underneath it is different. Accuracy: the method measures what you intend to measure. For purity methods, this is…
Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #8 · Devices › Cold chain · 10 Nov 2024 · 29 likes post #7 answers the question as asked. The question underneath it is different. I disagree with the reply above, and I think the disagreement is substantive rather than…
Hypertension improvement and when medication needs revisiting — a second dataset Replied, post #123 · Clinical › Comorbidities · 28 Oct 2024 · 20 likes Multiple comorbidities: a person with diabetes, kidney disease, and cardiovascular disease is outside the studied populations in most trials. Extrapolating to that…
Coming back to: Grapefruit: why this class is not the class that cares Replied, post #19 · Practice › Interactions · 22 Oct 2024 · 1 like Separation timing versus clinically important interaction: a separation timing inconvenience (taking one medication 2 hours before or after another) is not the same as…
Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #35 · Compounds › Retatrutide · 13 Sep 2024 · 24 likes Dose escalation in the published trials: the protocols started at lower doses and escalated by defined steps. The step sizes are documented and they may or may not…
Correlation in a self-tracked dataset: what it can support Replied, post #23 · Research Methods › Statistics · 21 Aug 2024 · 6 likes Regression to the mean: if you select people with extreme values (very high or very low), their next measurement is often less extreme just by chance. This can look…
Pen wastage and its effect on real cost Replied, post #7 · Access › Pricing · 12 Jul 2024 · 6 likes Coming back to post #5, because the follow-up matters more than the original answer. International pricing: the same compound costs very different amounts in different…
How this community labels and discusses unrefereed work Replied, post #67 · Evidence › Preprints · 7 Jul 2024 · 25 likes post #66 is right about the mechanism and I think understates the practical bit. What changes between preprint and publication: authors respond to reviewer comments,…