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n.silva

TL2 Moderator · Ilorin

Contributes reviews on supplier material. Based in Ilorin.

Joined 17 January 2025 · last posted 2d

99 posts, newest first. Showing up to 150.

  • Common supplements people ask about, assessed one at a time Replied, post #100 · Practice › Interactions · 26 Jul 2026 · 10 likes I read post #98 twice before replying, because I had assumed the opposite. Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K)…
  • Follow-up: Prior authorisation: what the criteria usually require Replied, post #95 · Access › Insurance & coverage · 25 Jul 2026 · 1 like Out-of-pocket costs: if insurance is not covering it, asking about patient assistance programmes run by manufacturers can reduce costs. Eligibility requirements exist…
  • Reading order for a first week here, and what to skip until later — what changed since Replied, post #70 · Start Here › Welcome · 22 Jul 2026 · 6 likes Marked solutions are the site's way of saying that someone asked a good question and someone else gave an answer that actually worked. It is not a competition and it…
  • Journal club: what we got wrong in an earlier session Replied, post #106 · Evidence › Journal club · 21 Jul 2026 · 10 likes This follows post #103 rather than contradicting it. FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early…
  • Second pass at: Sleep apnoea improving and the equipment implications Replied, post #89 · Wellbeing › Sleep · 19 Jul 2026 · 29 likes When sleep problems need attention: if sleep does not improve as weight loss continues or if it worsens, discussing with a clinician is prudent. Sleep disorders are…
  • Coming back to: Batch date after test date, and other internal inconsistencies Replied, post #17 · Analytics › COA interpretation · 18 Jul 2026 · 4 likes Water content (residual moisture) matters: lyophilised peptide is not dry. A few percent water is normal. The difference between a TFA salt and an acetate salt can be…
  • Endotoxin and why it is a separate question from purity — what changed since Replied, post #77 · Analytics › Impurities & related substances · 14 Jul 2026 · 9 likes Residual solvents: traces of solvents used in purification. These are usually tested by gas chromatography, not by HPLC. A specification for residual solvents should be…
  • NHS criteria and how they are applied in practice Replied, post #23 · Regional › UK & Ireland · 8 Jul 2026 · 7 likes Regional variation in NHS: access varies dramatically by region depending on local commissioning decisions and specialist service availability. Postcode determines…
  • Coming back to: Reconciling a supplier certificate with an independent result Replied, post #23 · Sourcing › Vendor reports · 8 Jul 2026 · 29 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
  • What is genuinely unknown about long-term amylin agonism Replied, post #13 · Compounds › Cagrilintide & amylin analogues · 8 Jul 2026 · 15 likes Nausea profile of amylin analogues: the historical agent pramlintide required multiple daily doses and had a difficult tolerability profile. A weekly formulation is a…
  • Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #20 · Compounds › Retatrutide · 27 Jun 2026 · 19 likes post #19 is right about the mechanism and I think understates the practical bit. Dose escalation in the published trials: the protocols started at lower doses and…
  • Prescription requirements and telehealth models — a second dataset Replied, post #72 · Sourcing › Regulatory · 20 Jun 2026 · 23 likes This follows post #69 rather than contradicting it. Compounding and pharmacy rules: some jurisdictions allow a pharmacy to compound a drug that is not on the market…
  • Lean mass preservation: what the evidence supports — does this still hold? Replied, post #98 · Outcomes › Body composition · 19 Jun 2026 · 5 likes Visceral fat: DXA does not distinguish visceral (organ-associated) fat from subcutaneous fat. That distinction might matter but requires different imaging to measure.
  • 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #68 · Devices › Syringes & needles · 10 Jun 2026 · 24 likes Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take…
  • What a certificate commits its issuer to — one year on Replied, post #85 · Analytics › COA interpretation · 9 Jun 2026 · 4 likes When a document puts the specification in the result column, it has told you the release criterion, not the measurement. Those are different claims and the second is…
  • CJC-1295 with and without DAC: what the modification does Replied, post #63 · Compounds › Secretagogues & GH axis · 21 May 2026 · 5 likes This follows post #60 rather than contradicting it. Development history is more informative than speculation: ipamorelin was investigated clinically for post-operative…
  • Splitting an overlong document into two Replied, post #19 · Documentation › Wiki requests · 15 May 2026 · 31 likes Translation suggestions: if a maintained page should exist in another language, suggesting it here helps the maintainers prioritise multilingual work.
  • A parcel stationary at a customs facility for nine days Replied, post #59 · Sourcing › Logistics · 14 May 2026 · 0 likes On post #55 — agreed on the reasoning, with one qualification. At what point is a parcel genuinely a problem: if it was despatched weeks ago and there has been no…
  • Historical amylin analogues and what happened to them Replied, post #8 · Compounds › Cagrilintide & amylin analogues · 14 May 2026 · 6 likes The CagriSema phase 2 paper: a fixed combination of the two components in one weekly injection. The trade-off of a fixed combination is that you cannot titrate the…
  • Journal club: orforglipron phase 2 and the non-peptide question Replied, post #59 · Evidence › Journal club · 9 May 2026 · 10 likes SELECT (N Engl J Med 2023): Semaglutide cardiovascular outcomes without diabetes. The first outcome trial in people without diabetes, which decoupled the cardiovascular…
  • Moderation log format change Replied, post #51 · Meta › Announcements · 8 May 2026 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
  • Tracking a shortage from primary sources rather than rumour Replied, post #2 · Access › Shortages · 6 May 2026 · 0 likes Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long the gap will be and how that affects your condition. Discussing with your…
  • The SOUL trial and oral semaglutide cardiovascular outcomes Replied, post #2 · Compounds › Oral incretins · 4 May 2026 · 0 likes Dose numbers for oral formulations are not comparable to injectable ones. The 14 mg oral dose is not equivalent to any injectable dose in the traditional comparison…
  • Reflectance and photometric devices: precision in practice — a second dataset Replied, post #21 · Analytics › Home & field testing · 3 May 2026 · 3 likes False positives and false negatives: no test has 100% sensitivity and 100% specificity. A negative result does not guarantee absence; a positive result does not…
  • Subgroup analyses: pre-specified versus discovered — a second dataset Replied, post #61 · Evidence › Trials · 26 Apr 2026 · 3 likes Absolute numbers, not just relative: a 30% relative reduction tells you the ratio but not the practical magnitude. The event rate in each arm and the difference between…
  • Prescription portability between countries Replied, post #14 · Access › International · 23 Apr 2026 · 28 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
  • Forced degradation studies: designing one that is informative Replied, post #41 · Analytics › Method validation · 21 Apr 2026 · 3 likes Why two laboratories may disagree: after validating the same method, they may still report different purity on the same sample due to integration differences, column…
  • [2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #42 · Devices › Syringes & needles · 19 Apr 2026 · 11 likes Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many…
  • Bioimpedance and hydration: why the number moves Replied, post #24 · Outcomes › Body composition · 30 Mar 2026 · 0 likes Bioelectric impedance analysis: less precise than DXA and strongly affected by hydration state. Not reliable for detecting month-to-month changes. Useful for trend over…
  • Journal club: is percentage weight change the right endpoint? Replied, post #18 · Evidence › Journal club · 27 Mar 2026 · 0 likes Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
  • Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Replied, post #66 · Practice › Storage & stability · 17 Mar 2026 · 11 likes Dating prepared solutions: write the date reconstitution on the vial in permanent marker. If you later need to know whether it has been sitting for weeks or days, the…
  • Second pass at: Identical chromatograms across two different lots Replied, post #58 · Sourcing › Red flags · 11 Mar 2026 · 24 likes Anonymity: a supplier that will not disclose legal name, address, or responsible person is not operating in a way that allows accountability.
  • Splitting a weekly dose in two: the pharmacokinetic argument against Replied, post #12 · Practice › Dosing & titration · 7 Mar 2026 · 5 likes Coming back to post #10, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
  • Anaesthesia and elective surgery: the aspiration question Replied, post #38 · Practice › Interactions · 3 Mar 2026 · 2 likes This follows post #35 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
  • Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #104 · Access › Pricing · 2 Mar 2026 · 31 likes Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented…
  • Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #43 · Analytics › Mass spectrometry · 20 Feb 2026 · 6 likes post #42 is right about the mechanism and I think understates the practical bit. Electrospray ionisation produces multiply charged ions. For a 4 kDa peptide you expect…
  • Personal import allowances, compared — a second dataset Replied, post #59 · Access › International · 28 Jan 2026 · 0 likes Insurance and coverage: coverage decisions are national. A compound approved in one country might not be covered by insurance in another. Checking both approval and…
  • Managing an unplanned gap in supply Replied, post #14 · Access › Shortages · 25 Jan 2026 · 0 likes Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.
  • Second pass at: Circumference measurements as a poor man's composition estimate Replied, post #38 · Outcomes › Body composition · 10 Jan 2026 · 0 likes Lean mass loss during rapid weight reduction: depends on protein intake, resistance training volume, and total energy deficit. Adequate protein and maintaining training…
  • The headache that turns out to be dehydration Replied, post #128 · Nutrition & Training › Hydration & electrolytes · 7 Jan 2026 · 18 likes Potassium: similar to sodium; losing weight involves some potassium loss. Bananas, sweet potatoes, and other potassium-rich foods help. Severe depletion is rare but…
  • Guidelines revision: what changed and why — one year on Replied, post #50 · Meta › Announcements · 24 Dec 2025 · 30 likes I read post #48 twice before replying, because I had assumed the opposite. Archives: older announcements are archived by date. Checking archives is useful if you want…
  • Reading an interaction checker output critically Replied, post #71 · Practice › Interactions · 20 Dec 2025 · 16 likes Coming back to post #69, because the follow-up matters more than the original answer. Oral medications versus time: if you take an oral medication 30 minutes before…
  • Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #24 · Clinical › Bloodwork · 7 Dec 2025 · 28 likes I read post #22 twice before replying, because I had assumed the opposite. Lipid panel interpretation: total, LDL, HDL, triglycerides all on one panel. Reading them…
  • Availability by country, dated, with primary sources Replied, post #68 · Access › International · 20 Nov 2025 · 0 likes Coming back to post #66, because the follow-up matters more than the original answer. Currency and exchange rates: paying in different currencies has different costs…
  • A parcel stationary at a customs facility for nine days Replied, post #6 · Sourcing › Logistics · 19 Nov 2025 · 16 likes Reshipment after seizure: if a parcel is seized, some suppliers will reship; others will not. That is a supplier choice and should be understood before ordering in a…
  • [2026 update] Storing lyophilised material long term: what governs the shelf life Replied, post #23 · Practice › Storage & stability · 15 Nov 2025 · 1 like Container choice matters: the material of the vial, the rubber closure, the fill volume all affect how quickly the contents degrade. Smaller fill volumes lose less to…
  • A comparison of home results against a laboratory result on the same vial Replied, post #55 · Analytics › Home & field testing · 28 Oct 2025 · 0 likes Coming back to post #53, because the follow-up matters more than the original answer. Why third-party testing is stronger: a home test run by the person who made the…
  • A 40-week log with the measurement method stated Replied, post #37 · Outcomes › Progress reports · 19 Oct 2025 · 1 like Medication changes: escalating dose, or adding or removing other medications, can affect the rate of weight loss. Documenting medication changes alongside weight makes…
  • How the vendor documentation pages are maintained, and by whom — what changed since Replied, post #75 · Sourcing › Vendor reports · 18 Oct 2025 · 0 likes Multiple services on one lot: agreement across two independent laboratories is stronger than a high number from one. Our vendor pages deliberately mix services for that…
  • Meeting a protein target on a suppressed appetite Replied, post #27 · Nutrition & Training › Protein & intake · 10 Oct 2025 · 0 likes Coming back to post #25, because the follow-up matters more than the original answer. Two things before anyone answers the substance. First, the context in the first…
  • Citing a preprint in a maintained document: our rule and its reasoning — does this still… Replied, post #46 · Evidence › Preprints · 29 Sep 2025 · 0 likes post #45 answers the question as asked. The question underneath it is different. Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on these…
  • Payment method and the leverage it gives you, ranked Replied, post #62 · Sourcing › Payments · 23 Sep 2025 · 3 likes Coming back to post #60, because the follow-up matters more than the original answer. Documentation and tax implications: payments you make for compounds might have…
  • A pen that felt like it delivered nothing: diagnosing it afterwards Replied, post #19 · Devices › Pens & autoinjectors · 17 Sep 2025 · 0 likes Priming: most pens require priming before the first use (injecting a small amount to fill the needle and line). Not priming can result in no dose being delivered on the…
  • Comparing my trajectory with the trial curves, carefully Replied, post #49 · Outcomes › Progress reports · 15 Sep 2025 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
  • Titles that describe the question, not the situation Replied, post #91 · Start Here › How to Ask · 8 Sep 2025 · 3 likes Avoid "any advice?" at the end. It is so generic that people do not know which part of the post it refers to. Pick the specific part and ask that specific question…
  • Revisiting: Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #21 · Practice › Administration · 10 Aug 2025 · 0 likes Injection discomfort: comes from needle gauge (finer = less discomfort), volume (smaller = less discomfort), temperature (room temperature or warmed is less…
  • Why a compound being unapproved is not the same as being illegal to possess Replied, post #9 · Sourcing › Regulatory · 10 Aug 2025 · 22 likes Worth separating two things that post #5 runs together. Regulatory positions change: a compound's status today might differ from its status a year from now. Citing a…
  • Coming back to: Oxidation and deamidation mass shifts, tabulated Replied, post #25 · Analytics › Mass spectrometry · 2 Aug 2025 · 29 likes Calibration matters: a high-resolution instrument out of calibration can report mass with ppm error large enough to be uninformative. Check when the instrument was last…
  • A ten-fold dose error caught before injection — one year on Replied, post #39 · Devices › Syringes & needles · 2 Aug 2025 · 2 likes I read post #37 twice before replying, because I had assumed the opposite. Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01…
  • Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #146 · Devices › Cold chain · 20 Jul 2025 · 28 likes I read post #144 twice before replying, because I had assumed the opposite. Shipment during summer or to hot climates: consider shipping to a cold-storage facility…
  • A supplier that answers analytical questions with restated claims Replied, post #114 · Sourcing › Red flags · 9 Jul 2025 · 26 likes Unresponsiveness: a supplier that does not reply to reasonable requests for documentation or clarification is showing you something about how they operate.
  • Sequence verification for an obscure compound: how it is done Replied, post #81 · Compounds › Other compounds · 3 Jul 2025 · 0 likes I read post #79 twice before replying, because I had assumed the opposite. AOD-9604 is a fragment of human growth hormone and has been discussed as a potential…
  • Vagal afferents and the gut-brain pathway Replied, post #9 · Pharmacology › Receptor biology · 27 Jun 2025 · 9 likes Picking up post #6: that is the part I would want checked first. Long-term receptor changes: very little is known about what happens to receptor expression, signalling,…
  • Gauge and length selection for subcutaneous injection Replied, post #3 · Devices › Syringes & needles · 5 Jun 2025 · 1 like Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and…
  • A claim built entirely on a subgroup analysis Replied, post #76 · Evidence › Study critique · 5 Jun 2025 · 0 likes Building consensus on which criticisms matter: if everyone agrees that the sample size is small but only you think that affects the conclusion, maybe your criticism is…
  • A report I filed that turned out to be wrong, and the correction Replied, post #68 · Sourcing › Vendor reports · 24 May 2025 · 0 likes Picking up post #65: that is the part I would want checked first. Blind submission is worth the effort: have someone else relabel the sample so neither you nor the…
  • Pregnancy as an absolute contraindication Replied, post #79 · Safety › Contraindications · 20 May 2025 · 3 likes Pregnancy: these compounds are not approved for pregnancy. The potential risks outweigh potential benefits. Planning windows and washout (several months) are the…
  • Delayed gastric emptying and oral medication absorption: which drugs matter Replied, post #69 · Practice › Interactions · 2 May 2025 · 0 likes Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows gastric emptying), the delayed stomach emptying affects when and…
  • Dizziness on standing: the ordinary explanation first Replied, post #22 · Nutrition & Training › Hydration & electrolytes · 28 Apr 2025 · 13 likes The very ordinary causes of week-two malaise: inadequate hydration, low sodium intake, too-rapid calorie deficit, and inadequate sleep are more common causes of fatigue…
  • Reading a trial's population section before its results — does this still hold? Replied, post #16 · Evidence › Trials · 17 Apr 2025 · 31 likes On post #12 — agreed on the reasoning, with one qualification. Confounding in observational data: a third variable can explain an apparent association. In a randomised…
  • Review: a draft on reconstitution arithmetic, with objections Replied, post #102 · Documentation › Doc review · 12 Apr 2025 · 11 likes Worth separating two things that post #98 runs together. Revision disputes: if you disagree with an edit a maintainer made to a page, discuss it here. The goal is…
  • Requesting a translation of an existing page Replied, post #7 · Documentation › Wiki requests · 7 Apr 2025 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
  • Reading order for a first week here, and what to skip until later Replied, post #64 · Start Here › Welcome · 2 Apr 2025 · 0 likes Your introduction is well framed. You have given enough context that people can actually answer. That is rarer than it sounds and it matters more than it sounds.
  • Second pass at: Pharmacy supply in the UK and the questions you will be asked Replied, post #24 · Regional › UK & Ireland · 21 Mar 2025 · 19 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
  • Maintainer handover: how it works Replied, post #79 · Meta › Wiki maintenance · 19 Mar 2025 · 14 likes Review dates: each maintained page has a review date (the date by which it should be checked). If a page is past its review date, flagging it here alerts the maintainer.
  • Follow-up: Open-label extensions: what survives and what does not Replied, post #12 · Evidence › Trials · 15 Mar 2025 · 30 likes Multiplicity and multiple comparisons: if a trial tests many hypotheses, the chance of a false positive on at least one by random chance increases. This is why…
  • Validating a method you did not develop — does this still hold? Replied, post #92 · Analytics › Method validation · 9 Mar 2025 · 6 likes On post #88 — agreed on the reasoning, with one qualification. Robustness: the method gives consistent results when minor parameters vary. Tested by deliberately…
  • Biased agonism: a real phenomenon, an over-used explanation Replied, post #49 · Pharmacology › Receptor biology · 6 Mar 2025 · 3 likes post #48 is right about the mechanism and I think understates the practical bit. Amylin receptor signalling: amylin promotes satiety and slows gastric emptying through…
  • Validating a method you did not develop — does this still hold? Replied, post #77 · Analytics › Method validation · 6 Mar 2025 · 3 likes Why two laboratories may disagree: after validating the same method, they may still report different purity on the same sample due to integration differences, column…
  • Enforcement priorities versus written rules Started this topic · Sourcing › Regulatory · 1 Mar 2025 · 0 likes Enforcement priorities versus written rules — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a…
  • Second pass at: Regression to the mean in progress reports Replied, post #63 · Research Methods › Statistics · 21 Feb 2025 · 0 likes Absence of evidence and evidence of absence: if a study is small and finds no effect, that is absence of evidence, not evidence of absence. A larger study might find an…
  • Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #66 · Evidence › Meta-analyses · 6 Feb 2025 · 10 likes Worth separating two things that post #62 runs together. Publication bias: what did not get published? Small studies with negative results are less likely to be…
  • Preservatives: function, testing, and limits Replied, post #8 · Pharmacology › Formulation chemistry · 6 Feb 2025 · 0 likes post #7 answers the question as asked. The question underneath it is different. Antioxidants: compounds that prevent oxidation (which damages peptides) are sometimes…
  • What changed in 2026, by region Replied, post #104 · Access › International · 27 Jan 2025 · 22 likes This follows post #101 rather than contradicting it. Customs and import outcomes: different routes have different seizure rates. Some countries are stricter on peptide…
  • Telehealth prescribing models in the US Replied, post #41 · Regional › North America · 3 Jan 2025 · 11 likes I read post #39 twice before replying, because I had assumed the opposite. Cross-border purchase: buying in the US and bringing to Canada or vice versa involves both…
  • Building a sensible monitoring schedule with your prescriber Replied, post #63 · Clinical › Bloodwork · 21 Dec 2024 · 0 likes A single value outside interval: usually uninformative on a single draw. What makes a result interesting: a trend across multiple draws, a magnitude well beyond the…
  • Gallbladder disease risk with rapid weight loss Replied, post #46 · Clinical › Comorbidities · 20 Dec 2024 · 5 likes Worth separating two things that post #42 runs together. Bariatric surgery history: altered anatomy after surgery affects absorption. That matters for oral medications…
  • Body image changing more slowly than the body Replied, post #45 · Wellbeing › Mental health · 16 Dec 2024 · 0 likes Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan…
  • Patterns that reliably precede a problem, documented Replied, post #4 · Sourcing › Red flags · 1 Dec 2024 · 20 likes Documentation quality as a signal: a supplier that reports method identifiers, distinguishes specification from result, and states the counter-ion form is telling you…
  • Follow-up: Oral contraceptives and delayed emptying: what the data shows Replied, post #24 · Practice › Interactions · 9 Nov 2024 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
  • SURPASS-2 and the comparator dose question that will not go away Replied, post #51 · Compounds › Tirzepatide · 8 Nov 2024 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
  • Second pass at: Hoarding and why it makes a shortage worse Replied, post #34 · Access › Shortages · 10 Oct 2024 · 4 likes International supply chains: a shortage in one country does not mean shortage in another. That is why ordering from multiple suppliers before a shortage gets bad is…
  • Reading a supplementary appendix and finding the interesting part Replied, post #4 · Evidence › Trials · 9 Oct 2024 · 0 likes Intent-to-treat versus per-protocol: ITT includes everyone assigned regardless of whether they took the drug. Per-protocol includes only those who completed it as…
  • Transit times by route, from a logged dataset — the long version Replied, post #12 · Sourcing › Logistics · 13 Sep 2024 · 19 likes Customs outcomes are not predictable at the level of an individual parcel. What is predictable is that consistent, accurate declarations correlate with fewer…
  • Progressive overload when the scale is falling — one year on Replied, post #51 · Nutrition & Training › Resistance training · 13 Sep 2024 · 5 likes post #50 answers the question as asked. The question underneath it is different. Frequency: three sessions per week of full-body training is easier to maintain than…
  • Reporting a discrepancy without making an allegation Replied, post #53 · Sourcing › Vendor reports · 1 Sep 2024 · 14 likes I read post #51 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
  • Pen wastage and its effect on real cost Replied, post #12 · Access › Pricing · 1 Aug 2024 · 9 likes On post #8 — agreed on the reasoning, with one qualification. List prices versus negotiated prices: the price a pharmaceutical company publishes and the price an…
  • Second pass at: A field-by-field walk through a certificate of analysis Replied, post #12 · Analytics › COA interpretation · 24 Jul 2024 · 30 likes Worth separating two things that post #8 runs together. Water content (residual moisture) matters: lyophilised peptide is not dry. A few percent water is normal. The…
  • How this community labels and discusses unrefereed work Replied, post #102 · Evidence › Preprints · 21 Jul 2024 · 1 like What changes between preprint and publication: authors respond to reviewer comments, re-analyse data, correct errors found in peer review, and sometimes report…