20 categories

Evidence

Published evidence, read closely. Trial digests, journal club, meta-analyses, preprints, and structured critique.

148 topics7,629 posts42 solved Moderators: s.leclerc, dr_okonkwo About this category

Trials 33 Journal club 47 Meta-analyses 24 Preprints 20 Study critique 24

148 topics · page 4 of 5

Topic	Participants	Replies	Views	Activity
A preprint whose numbers changed substantially at publication Evidence › Preprints preprint needs a source effect size Wiki Closed A preprint whose numbers changed substantially at publication — setting out what I have, and where I think it stops being reliable. Session topic: SURMOUNT-2 ( Lancet , 2023). Please read it before posting;…	+90	95	21k	9mo
Trial registration and comparing the protocol with the paper Evidence › Trials randomised trial open label intention to treat Trial registration and comparing the protocol with the paper — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim I do…	+38	44	4.8k	10mo
Citing a preprint in a maintained document: our rule and its reasoning — does this still hold? Evidence › Preprints preprint needs a source effect size Solved Under review The question in the title: Citing a preprint in a maintained document: our rule and its reasoning — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER…	+103	115	24k	10mo
Journal club: STEP-HFpEF and symptom endpoints — a second dataset Evidence › Journal club estimand risk of bias randomised trial journal club On the subject in the title: Journal club: STEP-HFpEF and symptom endpoints — a second dataset Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with STEP 4 ( JAMA , 2021) and…	+11	15	4k	10mo
Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? Evidence › Journal club journal club effect size number needed to treat Solved The question in the title: Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? I will give what I have already checked below so nobody repeats it. Session topic: STEP 4 (…		2	15k	10mo
Reverse causation in a cohort study of weight and outcome — a second dataset Evidence › Study critique risk of bias observational data confounding Reverse causation in a cohort study of weight and outcome — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+112	131	1.5k	10mo
Follow-up: Journal club: orforglipron phase 2 and the non-peptide question Evidence › Journal club randomised trial risk of bias effect size number needed to treat Posting this under the heading it deserves: Journal club: orforglipron phase 2 and the non-peptide question Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it…	+80	91	10k	11mo
When a preprint is the best available evidence and we say so Evidence › Preprints risk of bias effect size preprint Solved When a preprint is the best available evidence and we say so — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in…	+148	160	31k	11mo
Coming back to: Sample size calculations, read backwards from the published number Evidence › Trials estimand discontinuation & dropout surrogate endpoints randomised trial On the subject in the title: Sample size calculations, read backwards from the published number Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+82	88	1.8k	11mo
Journal club: STEP-HFpEF and symptom endpoints Evidence › Journal club journal club effect size estimand risk of bias Journal club: STEP-HFpEF and symptom endpoints — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURMOUNT-1 ( N Engl J Med , 2022) and finding…	+18	22	2.5k	11mo
Risk-of-bias tools and the judgement they conceal Evidence › Meta-analyses meta-analysis heterogeneity publication bias effect size Wiki Risk-of-bias tools and the judgement they conceal Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…	+8	12	21k	11mo
Criticising the method without criticising the authors — one year on Evidence › Study critique confounding effect size disputed risk of bias Solved Closed On the subject in the title: Criticising the method without criticising the authors — one year on Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting;…	+16	20	61k	11mo
Confounding by indication, explained with a concrete example Evidence › Study critique confounding observational data disputed On the subject in the title: Confounding by indication, explained with a concrete example Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-2 ( N Engl J Med ,…	+21	25	21k	11mo
Immortal time bias in a claims-database study Evidence › Study critique risk of bias observational data disputed confounding Closed Immortal time bias in a claims-database study — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+29	34	28k	11mo
The "under review" status pill and when a moderator applies it — a second dataset Evidence › Preprints needs a source risk of bias preprint effect size The "under review" status pill and when a moderator applies it — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021)…	+50	54	1.4k	11mo
[2026 update] Journal club: is percentage weight change the right endpoint? Evidence › Journal club effect size risk of bias randomised trial Journal club: is percentage weight change the right endpoint? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021) with…	+105	118	18k	11mo
[2026 update] Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses publication bias heterogeneity meta-analysis Heterogeneity as information rather than as a nuisance Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…		4	32k	11mo
Journal club: how we handle discontinuation in obesity trials Evidence › Journal club randomised trial effect size number needed to treat Solved Closed On the subject in the title: Journal club: how we handle discontinuation in obesity trials Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…		2	1.9k	12mo
Comparators chosen for regulatory reasons rather than clinical ones — one year on Evidence › Trials randomised trial intention to treat open label estimand Solved Comparators chosen for regulatory reasons rather than clinical ones — one year on — setting out what I have, and where I think it stops being reliable. Session topic: SURMOUNT-2 ( Lancet , 2023). Please read…	+82	87	1.1k	12mo
Journal club: STEP 8 and the fairness of the comparator dose Evidence › Journal club estimand number needed to treat journal club Journal club: STEP 8 and the fairness of the comparator dose — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 8 ( JAMA , 2022) and finding…	+2	6	39k	12mo
Journal club: SURMOUNT-1, read without the press release Evidence › Journal club journal club estimand randomised trial number needed to treat Journal club: SURMOUNT-1, read without the press release Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…	+139	157	66k	12mo
Journal club: the CagriSema phase 2 combination paper — a second dataset Evidence › Journal club journal club estimand effect size Solved Journal club: the CagriSema phase 2 combination paper — a second dataset — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a…	+74	79	2.3k	13mo
Random versus fixed effects: choosing rather than defaulting Evidence › Meta-analyses effect size publication bias risk of bias heterogeneity Closed Random versus fixed effects: choosing rather than defaulting — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before posting;…	+16	20	22k	13mo
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Evidence › Journal club randomised trial risk of bias effect size estimand Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with FLOW…	+58	64	17k	13mo
Interim analyses and stopping rules — does this still hold? Evidence › Trials estimand discontinuation & dropout open label surrogate endpoints Solved Interim analyses and stopping rules — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SCALE ( N Engl J Med , 2015) with SURMOUNT-4 (…	+30	34	29k	13mo
Journal club: STEP 4 and what a withdrawal design can prove Evidence › Journal club randomised trial risk of bias effect size Solved On the subject in the title: Journal club: STEP 4 and what a withdrawal design can prove Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+61	65	2k	13mo
Second pass at: Trial registration and comparing the protocol with the paper Evidence › Trials estimand discontinuation & dropout randomised trial open label Posting this under the heading it deserves: Second pass at: Trial registration and comparing the protocol with the paper Everything below is what sits behind that. I have seen SCALE ( N Engl J Med , 2015)…	+30	34	33k	13mo
Individual participant data versus aggregate data Evidence › Meta-analyses heterogeneity risk of bias meta-analysis publication bias Posting this under the heading it deserves: Individual participant data versus aggregate data Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…	+30	34	64k	14mo
When a preprint is the best available evidence and we say so — a second dataset Evidence › Preprints preprint risk of bias needs a source Solved When a preprint is the best available evidence and we say so — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med ,…	+20	24	36k	14mo
A claim built entirely on a subgroup analysis Evidence › Study critique risk of bias observational data confounding disputed Solved A claim built entirely on a subgroup analysis Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do…	+71	80	1.1k	14mo